ISSN

2231-3915 (Online)
2231-3907 (Print)


Author(s): Gayatri Sheshrao Chavan, Rahul D. Khaire

Email(s): gayatrichavan113@gmail.com

DOI: 10.52711/2231-3915.2023.00005   

Address: Gayatri Sheshrao Chavan*, Rahul D. Khaire
PRES College of Pharmacy (for Women) Chincholi, Nashik, 422102 Maharashtra India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2023


ABSTRACT:
Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital herpes, herpes stromal keratitis, meningitis and encephalitis. The intrinsic, innate and adaptive immune responses are key to control HSV, and the virus has developed mechanisms to evade them. The immune response can also contribute to pathogenesis, as observed in stromal keratitis and encephalitis. The fact that certain individuals are more prone than others to suffer severe disease upon HSV infection can be partially explained by the existence of genetic polymorphisms in humans. Like all herpesviruses, HSV has two replication cycles: lytic and latent. During lytic replication HSV produces infectious viral particles to infect other cells and organisms, while during latency there is limited gene expression and lack of infectious virus particles. HSV establishes latency in neurons and can cause disease both during primary infection and upon reactivation. The mechanisms leading to latency and reactivation and which are the viral and host factors controlling these processes are not completely understood.


Cite this article:
Gayatri Sheshrao Chavan, Rahul D. Khaire. Herpes simplex virus infection. International Journal of Technology. 2023; 13(1):45-9. doi: 10.52711/2231-3915.2023.00005

Cite(Electronic):
Gayatri Sheshrao Chavan, Rahul D. Khaire. Herpes simplex virus infection. International Journal of Technology. 2023; 13(1):45-9. doi: 10.52711/2231-3915.2023.00005   Available on: https://www.ijtonline.com/AbstractView.aspx?PID=2023-13-1-5


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