2231-3915 (Online)
2231-3907 (Print)

Author(s): Gupta Vishal, Gautam Girendra Kumar, Yadav S.K.


DOI: 10.5958/2231-3915.2017.00015.3   

Address: Gupta Vishal1 , Gautam Girendra Kumar2,Yadav S.K.3
1Research Scholar ,Institute of Pharmaceutical Science and Research Center, Bhagwant University, Ajmer, Rajasthan, India.
2Supervisor, Institute of Pharmaceutical science and research center, Bhagwant University, Ajmer, Rajasthan, India.
3Supervisor, Technocrat Institute of Technology –Pharmacy, Anand Nagar, Bhopal , India
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2017

A series of Benzimidazole derivatives were synthesized by condensation of N-(1H-benzimidazol-5-yl)- hydrazine carboxamide with various isatin derivatives and evaluated for their anti-inflammatory activity using carrageenan induced rat paw edema model. The synthesized compounds 7a-7h were characterized by spectral data (IR, 1H-NMR and mass) and elemental analysis. All the novel benzimidazole derivatives exhibited mild to moderate activity. Compound 7b, 5-methyl isatin derivative exhibited better anti-inflammatory activity compared with control and other test compounds with percentage inhibition of 71.75.

Cite this article:
Gupta Vishal , Gautam Girendra Kumar,Yadav S.K.. Synthesis, Characterization and Evaluation of substituted Benzimidazole hydrazine Carboxamide derivatives for Antiinflammatory activity.Int. J. Tech. 2017; 7(2): 90-95. doi: 10.5958/2231-3915.2017.00015.3

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DOI: 10.5958/2231-3915 

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