2231-3915 (Online)
2231-3907 (Print)

Author(s): Rajeswari Saripilli, Pikkala Shirisha


DOI: 10.52711/2231-3915.2021.00002   

Address: Rajeswari Saripilli*, Pikkala Shirisha
Department of Pharmaceutics, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram - 535002, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2021

The development of micro and nanobubbles as theranostics is been an emerging trend in the 21st century. Ultrasound molecular imaging is a real-time non-invasive, cost-effective, promising non-viral tool, which is been widely used in the recent times. These micro and nanobubbles are marked as ultrasound agents for both diagnosis and targeting therapeutic agents. These are designed in order to obtain efficient drug delivery. Micro and nanobubbles are very much used for targeting drug and achieving site specific release. These are stable and have longer residence time in systemic circulation, finally shows efficient and promising drug delivery [1]. These echogenic bubbles are helpful for disease diagnosis and therapy more prominently when compared with other novel drug delivery systems. This review describes about functioning of micro and nanobubbles along with mechanism, preparation and studies which describes the works on micro and nanobubbles.

Cite this article:
Rajeswari Saripilli, Pikkala Shirisha. Echogenic bubbles: An new avenue for cancer therapy. International Journal of Technology. 2021; 11(1):6-8. doi: 10.52711/2231-3915.2021.00002

Rajeswari Saripilli, Pikkala Shirisha. Echogenic bubbles: An new avenue for cancer therapy. International Journal of Technology. 2021; 11(1):6-8. doi: 10.52711/2231-3915.2021.00002   Available on:

1.    Batchelor DV, Abou-Saleh RH, Coletta PL, Laughlan JR, Peyman SA, Evans SD. Nested nanobubbles for ultrasound-triggered drug release. ACS applied materials & interfaces. 2020; 12: 29085-93.
2.    Jiaqi Z, Yihan C, Cheng D, Li Z, Zhenxing S, Jing W, Yali Y, Qing L, Wei H, Xie M. The optimized fabrication of a novel nanobubble for tumor imaging. Frontiers in Pharmacology. 2019: 10: 610.
3.    Gong Q, Gao X, Liu W, Hong T, Chen C. Drug-loaded microbubbles combined with ultrasound for thrombolysis and malignant tumor therapy. BioMed Research International. 2019.
4.    Wang LY, Zheng SS. Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy. Journal of Zhejiang University-SCIENCE B. 2019; 20(4): 291-299.
5.    Cai WB, Yang HL, Jain Z, Ji KY, Yi LY, Li JY, Li Z, Yun YD. The optimized fabrication of nanobubbles as ultrasound contrast agents for tumor imaging. Scientific Reports. 2015: 3 (5).      
6.    Khan MS, Jangsun H, Kyungwoo L, Yonghyun C, Kyobum K, Hyung-Jun K, Jong WH, Jonghoon C. Oxygen-carrying micro/nanobubbles: Composition, synthesis techniques and potential prospects in photo-triggered theranostics. Molecules. 2018: 23(9); 2210.
7.    Cavalli R, Soster M, Argenziano M. Nanobubbles: A promising efficient tool for therapeutic delivery. Therapeutic Delivery. 2016: 7(2); 17-38.
8.    Singh S, Sachdeva A, Gupta K, Singh S. Sonoporation: Therapeutic Ultrasonic Waves. Int J Oral Health Med Res. 2016: 3(1); 183-188.
9.    Fan Z, Kumon RE, Deng CX. Mechanisms of microbubble-facilitated sonoporation for drug and gene delivery. Therapeutic Delivery. 2014: 5(4):467-486.      
10.    Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Sueishi M. Sonoporation: Gene transfer using ultrasound. World Journal of Methodology. 2013: 3(4); 39.
11.    Duan L, Li Y, Juan J, Fang Y, Dong L, Ke H, Qinxin W, Yuanbin Y, Ning G. Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications. Theranostics. 2020: 10(2); 462.
12.    Stride E, Edirisinghe M. Novel microbubble preparation technologies. Soft Matter. 2008: 4(12); 2350-2359.
13.    Farook U, Stride E, Edirisinghe MJ, Moaleji R. Microbubbling by co-axial electrohydrodynamic atomization. Medical and Biological Engineering and Computing. 2007: 45(8); 781-789.   
14.    Wang Y, Li X, Zhou Y, Huang P, Xu Y. Preparation of nanobubbles for ultrasound imaging and intracelluar drug delivery. International Journal of Pharmaceutics. 2010: 384(1-2); 148-153.
15.    Devi GC, Kumar AE. Microbubbles - A potential novel targeted drug delivery. Research Journal of Pharmacy and Technology. 2019: 12(5); 2511-2516.   
16.    Astrid V, Martin B, Arne T, Andre Y, Mark M, Philipp P, Michael I, Clemens CC, Sigrid DA, Konstantin N, Maximilian FR, Franz P.      Ex vivo perfusion-simulation measurements of microbubbles as a scattering contrast agent for grating-based x-ray dark-field imaging. PloS One. 2015: 10(7); 1-14.  
17.    Nair AS, Tom RT, Suryanarayanan V, Pradeep T. ZrO 2 bubbles from core–shell nanoparticles. Journal of Materials Chemistry. 2003: 13(2); 297-300.   
18.    Cavalli R, Bisazza A, Lembo D. Micro and nanobubbles: a versatile non-viral platform for gene delivery. International Journal of Pharmaceutics. 2013: 456(2); 437-445.
19.    Rapoport NY, Kennedy AM, Shea JE, Scaife CL, Nam KH. Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles. Journal of Controlled Release. 2009: 138(3); 268-276.   
20.    Rix A, Curaj A, Liehn E, Kiessling F. Ultrasound microbubbles for diagnosis and treatment of cardiovascular diseases. SeminThrombHemost. 2019: 1.
21.    Zhou X, Guo L, Shi D, Duan S, Li J. Biocompatible chitosan nanobubbles for ultrasound-mediated targeted delivery of doxorubicin. Nanoscale Research Letters. 2019: 14(1); 24.
22.    Yuhang T, Zhao L, Lei Z, Jia Z, Xue H, Qiucheng W, Wen C. Apatinib-loaded lipid nanobubbles combined with ultrasound-targeted nanobubble destruction for synergistic treatment of HepG2 cells in vitro. OncoTargets and Therapy. 2018: 11; 4785.
23.    Qiaoya L, Hongyang L, Chengjun H, Zhouhong J, Changan L, Juan X, Wenwen M, Huisheng D. The use of 5-fluorouracil-loaded nanobubbles combined with low-frequency ultrasound to treat hepatocellular carcinoma in nude mice. European Journal of Medical Research. 2017: 22(1); 48.
24.    Marano F, Robert F, Letizia R, Monica A, Benedetta B, Cristina G, Raffaella M, Isabella C, Laura Berta, Roberta C, Maria GC. Combining doxorubicin-nanobubbles and shockwaves for anaplastic thyroid cancer treatment: preclinical study in a xenograft mouse model. Endocrine-Related Cancer. 2017: 24(6); 275-286.
25.    Zhang Y, Chang R, Li M, Zhao K, Zheng H, Zhou X. Docetaxel-loaded lipid microbubbles combined with ultrasound-triggered microbubble destruction for targeted tumor therapy in MHCC-H cells. OncoTargets and Therapy. 2016: 9; 4763.
26.    Deng L, Li L, Hong Y, Fenglong Z, Chunhui Wu, Yiyao L. Development and optimization of doxorubicin loaded poly (lactic-co-glycolic acid) nanobubbles for drug delivery into HeLa cells. Journal of Nanoscience and Nanotechnology. 2014: 14(4); 2947-2954.
27.    Caixiu P, Shufang C, Jiangchuna S, Shenyin Z, Hongxia L, Yi Z, Zhigang W, Ronald XX .  Ultrasound-mediated destruction of LHRHa-targeted and paclitaxel-loaded lipid microbubbles for the treatment of intraperitoneal ovarian cancer xenografts. Molecular Pharmaceutics. 2014 Jan 6; 11(1): 49-58.
28.    Escoffre JM, Piron J, Novell A, Bouakaz A. Doxorubicin delivery into tumor cells with ultrasound and microbubbles. Molecular Pharmaceutics. 2011: 8(3); 799-806.
29.    Lentacker I, Geers B, Demeester J, De Smedt SC, Sanders NN. Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved. Molecular Therapy. 2010: 18(1); 101-108.

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